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Trazodone for sleep uk (5); and for insomnia in the UK (6). benefits of antidepressants in the treatment OA of knee, and their anti-inflammatory effects, have been described previously. The aim of this study was to investigate the efficacy of prescription a selective serotonin reuptake inhibitor (SSRI), fluoxetine, in the treatment of mild to moderate OA the knee. MATERIALS AND METHODS Subjects Forty-one men (age, 53.4 ± 1.2 years, body mass index [BMI], 25.8 ± 2.0 kg/m2; range, 40-72 years), who had a diagnosis of mild to trazodone buy uk moderate OA Trazodone 100mg $103.68 - $0.86 Per pill the knee according to National Institute of Health criteria, participated in the study. These patients were recruited from two London local pharmacies. Each patient gave written informed consent approved by the local research ethics committee. protocol was reviewed and approved by the local research ethics committee. Outcome measures and assessments In each patient, a knee examination by two trained clinicians, using a standardised method of screening and assessment symptoms, was performed. The examinations used a standardized instrument, the Biosensors Assessment System (BAS-10), to determine the status of knee. Patients who met the criteria for non-specific can you buy trazodone over the counter knee pain (n = 10), arthralgia 12) or tenderness (n = 18) on the initial visual assessment were followed up for four weeks with a follow-up assessment, at which time the patients were randomly allocated for either oral fluoxetine or placebo treatment. The active treatment was started in the patients who had not yet achieved benefit with CBT for OA; it was considered to be started when the baseline score was at least 2. After 4 weeks, the patients were randomly assigned for either of the following two interventions for five weeks: a placebo period (control) or single dose of fluoxetine to a population ten patients per condition. This was to control for side effects. ensure sufficient numbers of patients in each condition, the control period for each patient began on day 3 and ended 15, whereas the first dose of fluoxetine to each patient was trazodone 100 mg to sleep given on day 1. For the ten patients who received fluoxetine, there was total blinding of the researchers and patient (who was not familiarised with the treatment) during active treatment, to ensure that there was no change in the level of symptom improvement during the treatment period. placebo period was a sham experimental where the treatment was not active and the patients received no treatment. In addition, all patients the placebo group were given a reference dose of placebo, which was the same as that prescribed after fluoxetine treatment. Statistical analyses The results for all statistical analyses are presented as mean (±s.e.m.) unless stated otherwise. We performed repeated measures analysis of variance (ANOVA) to test for differences in change from baseline between the placebo and fluoxetine conditions. Differences were evaluated using the Wilcoxon rank sum test for categorical variables and the t-test for continuous variables. analyses of the pain characteristics, Student's t-test, and the Kruskal-Wallis one-sample correlation test were used. Data are presented as the mean ±s.e.m., unless stated otherwise. RESULTS The baseline data for all patients, including those who completed the study, were analysed with use of a pre-test (2 weeks before randomisation to the second intervention or sham-controlled period) and a post-test on the same day. In placebo group, the initial BAS-10 (measuring knee pain and tenderness; BAS-9 in Figure ) was at least 2. The BAS-10 scores in all participants with pain were significantly higher than the BAS-9 values at each visit. The BAS-9 scores also gradually increased during the treatment period, although they continued to be relatively constant (Table ). Table 1 Baseline BAS-9 BAS-10 Change from % Treatment 1 7.5 ± 3.0 7.1 2.8 8.7 2.4 −2.6 ± 0.8 +2.0 0.0 0.2 −0.1 ± 0.1 Treatment 2 5.5 1.9 5.2 ± 1.8 5.7 0.3 0.2 −0.3 ± 0.0 0.1 −0.1 Treatment 3 2.8 ± 0.6 2.7 0.7 −3.6 −1.7 ± 0.0 0.1 −0.2 Treatment 4 2.1 ± 0.4 2.
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